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Check out the latest issue of Developmental Cell! We're quite proud to work with this team! What can Peregrine do for YOUR next project?
On the cover: The exponential increase in number of nuclei during development in early Drosophila embryos requires a massive amount of dinucleotide triphosphates (dNTPs). The runner represents ribonucleotide reductase (RNR), the rate-limiting enzyme of dNTP synthesis that is allosterically inhibited by the maternally deposited dNTPs. As DNA polymerization depletes maternal stores, the inhibition on RNR is lifted, allowing the embryo to start synthesizing dNTPs to meet the demand. To learn about the discovery of this regulatory loop, see Song et al, pp. 301–308. Cover design by Stas Shvartsman (Princeton), Yonghyun Song (Princeton), and Jeremy Guay (Peregrine Creative).