Cell Metabolism 01 May 2018, Volume 27, Issue 5 – On the cover: Aging leads to tissue NAD depletion, but we remain largely in the dark regarding the basic mechanisms controlling mammalian NAD levels. Here Liu et al. (pp. 1067–1080) use mass spectrometry to elucidate the metabolic flux of NAD across tissues by administering isotope-labeled NAD precursors, including the amino acid tryptophan, the vitamin nicotinamide (NAM), and the nutraceutical nicotinamide riboside (NR). They reveal that circulating NAM, made by the liver, is the main source of tissue NAD, and that oral NR reaches tissues in the form of NAM. The cover image captures a scientist with a beaming flashlight representing the isotope-tracing methodology that illuminates the “flux of the fox”—a sly and surreptitious fellow coursing through the body, transforming from NAD precursors and leaving post-hepatic NAM tracks. Illustration provided by Jeremy Guay of Peregrine Creative, LLC.
Check out the latest cover of Cell Metabolism – another great illustration project working with our clients at Princeton University. This one resulted in some pretty unique watercolor art in a "storybook" style.
"On the cover: Given growing health concerns of the effects of sugar (fructose) on metabolic disease, Jang et al. (pp. 351–361) track the fate of glucose and fructose carbons in vivo and show that, contrary to common belief, most dietary fructose is cleared by the small intestine rather than the liver. Higher doses of fructose eventually spill over to the liver to be metabolized. The cover image captures the concept of the small intestine acting as a shield to protect the liver from fructose. Illustration provided by Jeremy Guay of Peregrine Creative, LLC."
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